Bioinformatics and Biological Databases
Big idea: This Grade 12 capstone connects sequence alignment, database accession, homology search, functional annotation, reproducible workflow to evaluate complex biological systems through evidence, uncertainty, responsible inference and real-world application.
Learning goals
- sequence alignment
- database accession
- homology search
- functional annotation
- reproducible workflow
Core concepts
An arrangement of DNA, RNA or protein sequences that exposes matches, substitutions and gaps for comparison.
A stable unique identifier that links a deposited biological record to its sequence, metadata and version history.
A computational search for sequences similar because of shared evolutionary ancestry.
Assignment of evidence-based biological roles to sequence features, genes or proteins.
A documented, versioned analysis whose data, parameters and code allow others to repeat the result.