Genomics, Transcriptomics and Proteomics
Big idea: This Grade 12 capstone connects genome, transcriptome, proteome, differential expression, multi-omics integration to evaluate complex biological systems through evidence, uncertainty, responsible inference and real-world application.
Learning goals
- genome
- transcriptome
- proteome
- differential expression
- multi-omics integration
Core concepts
genome
The complete DNA sequence of an organism or cell, including coding and noncoding regions.
transcriptome
The full set of RNA molecules expressed in a cell or tissue under specified conditions and time.
proteome
The complete, condition-dependent set of proteins and protein forms present in a biological system.
differential expression
A statistically supported difference in RNA or protein abundance between defined biological conditions.
multi-omics integration
Joint analysis of genomic, transcriptomic, proteomic or metabolic layers to explain a biological phenotype.